I would advise you to carry and pack things according to your Destination, Duration, Weather, Activities, Type of Visit (Business, wedding, shopping, exploration), plan with family / solo.
Keeping everything organized is a challenge. As we are in a hurry most of the time, I generally pack layers starting from things that I would not need the most to the products that I might need quite often. I would generally carry lightweight clothes and try folding them properly so that it occupies less space and it fits in my bag properly
If you are planning to do a lot of activities. I would advise you to hire any types of equipment at that particular destination as you could save some space while packing and use that space for other stuff